Selected Publications
Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez-Hidalgo CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nature Communications 2016 Nov;7:13516. URL: http://www.nature.com/articles/ncomms13516


Sugiyama M*, Gamage A*, Zyla R, Armstrong SM, Wang C, Advani S, Advani A, Lee WL. Influenza infection induces platelet-endothelial adhesion that contributes to lung injury.
Journal of Virology 2016 Feb;90(4):1812-23. PMID: 26637453

Lee WL, Klip A. Endothelial transcytosis of insulin: Does it contribute to insulin resistance?
Physiology (Bethesda) 2016 Sept; 31(5):336-45. PMID 27511460.
Physiology_review_2016__1_.pdf
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Steinberg BE, Goldenberg NM, Fairn GD, Kuebler WM, Slutsky AS, Lee WL. Is basic science disappearing from medicine? The decline of biomedical research in the medical literature.
The Faseb Journal 2016 Feb;30(2):515-8. PMID: 26467794 FASEB_J-2016-Steinberg-515-8.pdf
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Armstrong S, Sugiyama M, Fung YY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu S-N, Neculai D, Yin C, Bolz S-S, Seidah N, Cybulsky M, Heit B, Lee WL. A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.
Cardiovascular Research 2015 Nov 1;108(2):268-77.
URL: https://academic.oup.com/cardiovascres/article/108/2/268/275330/A-novel-assay-uncovers-an-unexpected-role-for-SR?searchresult=1

Sugiyama MG, Armstrong SM, Wang C, Hwang D, Leong-Poi H, Advani A, Advani S, Szaszi K, Tabuchi A, Kuebler WM, Van Slyke P, Dumont DJ, Lee WL. The Tie2-agonist Vasculotide rescues mice from severe influenza virus infection. Scientific Reports 2015;5: 11030 doi:10.1038/srep11030ScientificReports. URL: www.nature.com/srep/2015/150605/srep11030/full/srep11030.html

Pillon N, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP, Heit B, Bilan PJ, Lee WL*, Klip A*.
Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promotes monocyte adhesion and impairs insulin transcytosis. American Journal of Physiology - Endocrinology and Metabolism 2015 Jul 1;309(1):E35-44. PMID: 25944880

Wang C*, Armstrong SM*, Sugiyama MG, Tabuchi A, Krauszman A, Kuebler WM, Mullen B, Advani S, Advani A, Lee WL (2015). Influenza primes human lung microvascular endothelium to leak upon exposure to Staphylococcus aureus. American Journal of Respiratory Cell and Molecular Biology 2015 Oct;53(4):459-70. Influenza_primes_the_lung_to_leak_AMJRCMB_2015.pdf
1.6 MB


Azizi PM, Zyla RE, Guan S, Wang C, Liu J, Bolz S-S, Heit B, Klip A, Lee WL (2014). Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells. Molecular Biology of the Cell 2015 Feb 15;26(4):740-50. doi: 10.1091/mbc.E14-08-1307. Epub 2014 Dec 24. Mol._Biol._Cell-2015-Azizi-740-50.pdf
5.7 MB



 Goldenberg NM, Leligdowicz A, Slutsky AS, Friedrich JO, Lee WL (2014). Is nosocomial infection really the major cause of death in sepsis? Critical Care 2014, 18:540  doi:10.1186/s13054-014-0540-y. PMID: 25672933. URL: http://ccforum.com/content/18/5/540

Armstrong SM, Mubareka S, Lee WL (2013).  The lung microvascular endothelium as a therapeutic target in severe influenza.  Antiviral Research 2013 Aug;99(2):113-8. doi: 10.1016/j.antiviral.2013.05.003. 

Armstrong SM, Wang C, Tigdi J, Si X, Dumpit C, Charles S, Gamage A, Moraes, TJ, & Lee WL (2012) Influenza Infects Lung Microvascular Endothelium Leading to Microvascular Leak: Role of Apoptosis and Claudin-5. Plos One 7(10):e47323.  URL: http://dx.plos.org/10.1371/journal.pone.0047323

Lee WL, Klip A (2012). Shuttling glucose across brain microvessels, with a little help from GLUT1 and AMP kinase. Focus on AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress and AMP kinase.  Am J Physiol Cell Physiol. 303(8):C803-5

Armstrong SM, Khajoee V, Wang C, Wang T, Tigdi J, Yin J, Kuebler WM, Gillrie M, Davis SP, Ho M, Lee WL. (2012). Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. The American Journal of Pathology, 180(3), 1308–23. URL: http://www.sciencedirect.com/science/article/pii/S0002944011010893

Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA. (2012). The CXCR4 / CXCR7 / SDF-1 pathway contributes to the pathogenesis of Shiga toxin – associated hemolytic uremic syndrome in humans and mice.  Journal of Clinical Investigation 122(2):759-76. 

Goldenberg NM, Steinberg BE, Slutsky AS, Lee WL (2011). Broken barriers: a new take on sepsis pathogenesis. Science Translational Medicine, 3(88), 88ps25. Science_Translational_Medicine_2011_Pathogenesis_of_Sepsis.pdf
652.9 KB


Lee WL, Slutsky AS (2010). Sepsis and Endothelial Permeability.  N Engl J Med. 363(7):689-91.nejmcibr1007320.pdf
521.4 KB


Steinberg BE, Goldenberg NM, Lee WL (2011).Do viral infections mimic bacterial sepsis?  The role of microvascular permeability: a review of mechanisms and methods.  Antiviral Res. 2012 Jan;93(1):2-15. 

Lee WL, Liles WC.  Endothelial activation, dysfunction and permeability during severe infections.  Curr Opin Hematol. 2011 May;18(3):191-6.



View more recent publications on PubMed

(below): Immunofluorescence of primary human coronary artery endothelial cells for caveolin-1 (green) and beta-tubulin (red).